In nature, baculoviruses occur as virions that are occluded within proteinaceous crystals known as polyhedra on plant foliage, plant debris and soil. These virions are rod-shaped (hence the term ‘baculo’) and measure 40–50 nm in diameter and 200–400 nm in length2. Their genome is circular, covalently closed and double-stranded of 88–200 kb. The infection cycle is divided into three phases: early, late and very late. During the early phase, there is transcription of genes whose products are essential for viral DNA replication, and these genes are transcribed by the RNA polymerase encoded by the host. |