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explain about mutation that caused by the changes in the chromosome number and structure.
There are several causes of chromosomes mutation. Each of these mutations can cause a variety of different diseases and conditions.
    The causes of chromosomes mutation occur when there is any change in the arrangement or structure of the chromosomes. These mutations occur most often during meiosis during the stage when crossing over occurs. There are several different mutation types that result in chromosomal structure change. This change in structure leads to serious changes in an organisms' phenotype and genotype. If essential parts of the DNA are affected by chromosomal mutations, a foetus can be aborted prior to birth without the mother's control. Mutations are either acquired or inherited from a parent. This cause of mutation occurs when a piece of one chromosome is transferred to a non-homologous chromosome. The two chromosomes, that are often reciprocal, swap segments with each other.
 This genetic mutation is often responsible for chronic myelogenous leukemia. This is because Philadelphia chromosome, a chromosomal abnormality, being shared with leukemic cells. A reciprocal translocation between the 9 and 22 chromosomes cause this abnormality due to the creation of an abnormal hybrid gene. This hybrid gene leads to a novel protein, not found in normal cells, being produced. When it is produced, normal development and growth are prevented, resulting in leukemia.


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