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neuron transport along a concenteration gradient is based on k+ and Na+ ions how it can be explained?
The Na+/K+ pump is found in the membranes of many types of cells. In particular, it plays a very important role in nerve cell membranes. Notice that 3 positive ions (Na+) are pumped out of the cell (towards ECF) for every 2 positive ions (K+) pumped into the cell (towards ICF). This means that there is more positive charges leaving the cell than entering it. As a result, positive charge builds up outside the cell compared to inside the cell. The difference in charge between the outside and inside of the cell allows nerve cells to generate electrical impulses which lead to nerve impulses.

The Na+/K+ pump has "active transport" since it moves Na+ and K+ against their concentration gradients. That is because there is already a high concentration of Na+ outside the cell and a high concentration of K+ inside the cell. In order to move the ions (Na+ and K+) againts their gradients, energy is required. This energy is supplied by ATP (adenosine triphosphate). An ATP molecule floating inside the cell, binds to the pump transferring some energy to it. As the energy is used, the ATP falls off and having lost its energy it is converted into ADP (adenosine diphosphate).
There are 3 binding sites for the 3 Na+ ions on the inner surface of the pump and 2 binding sites for the 2 K+ ions on the outer surface of the pump. The shape of these binding sites ensures that only Na+ and K+ can bind and be transported.

Since the pump requires an ATP every time it works, ATP must be constantly supplied to the cell. ATP is created during the processes called "cellular respiration" which occur inside the cell (in the ICF). Part of cellular respiration happens in the cytoplasm and part happens in the mitochondrion. Since these organelles are part of the nerve cell, as the ATP is made, it floats up to the pump and provides its energy. More ATP is made and the pump continues to do its job. If something interferes with the production of ATP, the pump will stop working and the nerve cell will also stop working. This can cause serious loss of nerve function and even death. Since cellular respiration requires oxygen, if you were to stop breathing, ATP could not be produced and you would die.


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